Important Safety Information about TOPROL-XL
WARNING: ISCHEMIC HEART DISEASE: Following abrupt cessation of therapy with
beta-blocking agents, exacerbations of angina pectoris and myocardial infarction
have occurred. Warn patients against interruption or discontinuation of therapy
without the physician’s advice. See WARNINGS: Metoprolol Succinate; Ischemic
Heart Disease in the full PI.
- TOPROL-XL is contraindicated in severe bradycardia, heart block of second or third degree, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome (unless permanent pacemaker is in place), and in patients who are hypersensitive to any component of this product
- Worsening cardiac failure may occur during up-titration of TOPROL-XL
- TOPROL-XL should be used with caution in patients who have bronchospastic disease, pheochromocytoma, diabetes and hypoglycemia, hepatic impairment, thyrotoxicosis, peripheral vascular disease, those who take calcium channel blockers of the verapamil and diltiazem type, or those who are undergoing major surgery
- Avoid initiation of high-dose TOPROL-XL in patients undergoing non-cardiac surgery
- Patients taking beta blockers with a history of anaphylactic reaction may be unresponsive to the usual doses of epinephrine used to treat allergic reactions
- The most common adverse reactions were tiredness, dizziness, depression, shortness of breath, bradycardia, hypotension, diarrhea, pruritus, and rash
Indication for TOPROL-XL
Toprol-XL is indicated for
- The treatment of hypertension, alone or in combination with other antihypertensives
- The long-term treatment of angina pectoris
- The treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin
Click here for full Prescribing Information for TOPROL-XL, including Boxed WARNING regarding ischemic heart disease.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.