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WARNING: Because of the possibility of serious side effects, such as chest pain or a heart attack, you should not stop taking TOPROL-XL suddenly. If your doctor decides you should stop taking TOPROL-XL, you may be instructed to slowly reduce your dose over a period of time before stopping it completely.

TOPROL-XL may not be right for everyone, especially people who have the following health conditions:

• Extreme slowing of the heart rate
• Sudden and severe drop in blood pressure and blood flow through the body because the heart is not pumping normally
• Uncontrolled heart failure
• Slowdown of the heart’s electrical signal causing a slower heart rate
• Damage to the heart’s natural pacemaker that affects the heart’s rhythm unless one has a pacemaker device
• Any allergies to TOPROL-XL or its ingredients

It is important to take your medications every day as directed by your doctor.

Patients who have asthma or asthma-like lung disease should, in general, not take TOPROL-XL.

Your doctor may not want you to take TOPROL-XL if you are currently taking certain types of high blood pressure medicine, or have adrenal gland tumors, diabetes, low blood sugar, liver damage, overactive thyroid disease, or hardening of the arteries in the arms or legs.

Your doctor may not want you to start taking TOPROL-XL if you are about to have any type of surgery.

If you have a history of serious allergic reactions, the usual dose of epinephrine (adrenaline) may not work as well if you are taking TOPROL-XL.

Until you know how you will react to TOPROL-XL, avoid activities that require alertness.

Contact your doctor if you have any difficulty in breathing.

In patients with high blood pressure, the most common side effects were tiredness, dizziness, depression, diarrhea, itching or rash, shortness of breath, and slow heart rate. If you experience any of these or other side effects, contact your doctor.

Approved Use for TOPROL-XL:

TOPROL-XL is approved for the treatment of high blood pressure. It may be used alone or in combination with other medications to treat high blood pressure. It’s good for you to know more about your medical condition and the medicine you are taking for it, so talk to your doctor about high blood pressure and TOPROL-XL.

Click here for the full Prescribing Information, including Boxed WARNING about suddenly stopping therapy with TOPROL-XL.